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論文目録

2017

  • Catalyst-Controlled Site-Selective Asymmetric Epoxidation of Nerylamine and Geranylamine Derivative
    T. Nobuta, T. Kawabata
    Chem.Commun., 53(67), 9320-9323 (2017).
  • Determination of urinary 15α-hydroxyestrogen levels via immunoaffinity extraction.
    M. Nakagomi and E. Suzuki, J Chromatogr B Analyt Technol Biomed Life Sci., 1060, 336-339 (2017).

2016

  • Hydrogen Bonding to Carbonyl Oxygen of Nitrogen-pyramidalized Amide-Detection of Pyramidalization Direction Preference by Vibrational Circular Dichroism Spectroscopy.
    S. Wang, T. Taniguchi, K. Monde, M. Kawahata, K. Yamaguchi, Y. Otani, and T. Ohwada, Chem.Commun., 52(21), 4018-4021(2016).
  • Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.
    S. Jung, A.Inoue, S. Nakamura, T. Kishi, A. Uwamizu, M. Sayama, M. Ikubo, Y. Otani, K. Kano, K. Makide, J. Aoki, and T. Ohwada, J. Med.Chem., 59(18), 3750-3776 (2016).

2015

  • Elucidation and Total Synthesis of the Correct Structures of Tridecapeptides Yaku'amides A and B. Synthesis-Driven Stereochemical Reassignment of Four Amino Acid Residues.
    T. Kuranaga, H. Mutoh, Y. Sesoko, T. Goto, S. Matsunaga, and M. Inoue, J. Am. Chem. Soc., 137(29), 9443-9451(2015).
  • 「光スイッチを持つGタンパク質共役型受容体のアロステリックモジュレーター」
    中込まどか,ファルマシア,トピックス,51 (3), 252 (2015).

2014

  • Development of novel silicon-containing inverse agonists of retinoic acid receptor-related orphan receptors.
    H. Toyama, M. Nakamura, M. Nakamura, Y. Matsumoto, M. Nakagomi, and Y. Hashimoto, Bioorg. Med. Chem., 22, 1948-1959 (2014).
  • Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand.
    Y. Nishiyama, M. Nakamura, T. Misawa, M. Nakagomi, M. Makishima, M. Ishikawa, and Y. Hashimoto, Bioorg. Med. Chem., 22, 2799-2808 (2014).
  • Cooperative therapeutic action of retinoic acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer's disease.
    K. Kawahara, M. Suenobu, H. Ohtsuka, A. Kuniyasu, Y. Sugimoto, M. Nakagomi, H. Fukasawa, K. Shudo, and H. Nakayama, J. Alzheimers Dis., 22, 587-605 (2014).
  • Diarylamines Incorporating Hexahydrophenalene or Octahydrobenzoheptalene as Retinoid X Receptor (RXR)-Specific Agonists.
    Y. Amano, M. Noguchi, and K. Shudo, Chem. Pharm. Bull., 62(3), 254-259 (2014).

2013

  • The Retinoic Acid Receptor Agonist Am80 Increases Hippocampal ADAM10 in Aged SAMP8 Mice.
    K. Kitaoka, N. Shimizu, K. Ono, S. Chikahisa, M. Nakagomi, K. Shudo, K. Ishimura, H. Séi, and K. Yoshizaki, Neuropharmacology, 72, 58-65 (2013).
  • A Retinoic Acid Receptor Agonist Tamibarotene Suppresses Iron Accumulation in the Liver.
    O. Yoshikawa, Y. Ebata, H. Tsuchiya, A. Kawahara, C. Kojima, Y. Ikeda, S. Hama, K. Kogure, K. Shudo, and G. Shiota, Obesity, 21(1), E22-E25 (2013).
  • Retinoid Agonist Am80-enhanced Neutrophil Bactericidal Activity Arising from Granulopoiesis in vitro and in a Neutropenic Mouse Model.
    W. Ding, H. Shimada, L. Li, R. Mittal, X. Zhang, K. Shudo, Q. He, N. V. Prasadarao, and L. Wu, Blood, 121(6), 996-1007 (2013).
  • Am80, a Retinoic Acid Receptor Agonist, Ameliorates Murine Vasculitis Through the Suppression of Neutrophil Migration and Activation.
    C. Miyabe, Y. Miyabe, N. N. Miura, K. Takahashi, Y. Terashima, E. Toda, F. Honda, T. Morio, N. Yamagata, N. Ohno, K. Shudo, J. Suzuki, M. Isobe, K. Matsushima, R. Tsuboi, N. Miyasaka, and T. Nanki, Arthritis Rheum., 65(2), 503-512 (2013).
  • Potent Oxazolidinone Antibacterials with Heteroaromatic C-Ring Substructure.
    H. Suzuki, I. Utsunomiya, K. Shudo, T. Fujimura, M. Tsuji, I. Kato, T. Aoki, A. Ino, and T. Iwaki, ACS Med. Chem. Lett., 4(11), 1074-1078 (2013).
  • A Novel Aromatic Carboxylic Acid Inactivates Luciferase by Acylation of an Enzymatically Active Regulatory Lysine Residue.
    M. Nakagomi, N. Fujimaki, A. Ito, T. Toda, H. Fukasawa, K. Shudo, and R. Tomita, PLoS ONE, 8(9), e75445 (2013).
  • Synthesis and in vitro/in vivo Antibacterial Activity of Oxazolidinones Having Thiocarbamate at C-5 on the A-ring and an Amide- or Urea-substituted [1,2,5]Triazepane or [1,2,5]Oxadiazepane as the C-ring.
    H. Suzuki, I. Utsunomiya, K. Shudo, N. Fukuhara, T. Iwaki, and T. Yasukata, Eur. J. Med. Chem., 69, 262-277 (2013).
  • Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites.
    H. Muratake, Y. Amano, T. Toda, K. Sugiyama, and K. Shudo, Chem. Pharm. Bull., 61(8), 846-852 (2013).
  • Design, Synthesis and Evaluation of Retinoids with Novel Bulky Hydrophobic Partial Structures.
    Y. Amano, M. Noguchi, M. Nakagomi, H, Muratake, H. Fukasawa, and K. Shudo, Bioorg. Med. Chem., 21(14), 4342-4350 (2013).
  • Deprotonation Equilibrium of 5-Tropolonediazonium Salt Strongly Favors 1,2,5-Tropoquinone-5-diazide Structure in Certain Solvents.
    A. Ito, H, Muratake, and K. Shudo, J. Org. Chem., 78(11), 5470-5475 (2013).
  • Antibacterial Oxazolidinone Aanalogues Having a N-Hydroxyacetyl-substituted Seven-membered [1,2,5]Triazepane or [1,2,5]Oxadiazepane C-ring Unit.
    H. Suzuki, I. Utsunomiya, K. Shudo, N. Fukuhara, T. Iwaki, and T. Yasukata, Eur. J. Med. Chem., 63, 811-825 (2013).
  • Synthetic Retinoid Am80 Results in Improved Exploratory and Emotionalbehavior in the P8 Substrain of Senescence-accelerated Mice.
    M. Nakagomi, K. Shudo, and A. Nakatani-Pawlak, Pharmacol. Biochem. Behav., 104, 1-9 (2013).
  • Structure-activity Relationship Study on Benzoic Acid Part of Diphenylamine-based Retinoids.
    K. Ohta, E. Kawachi, K. Shudo, and H. Kagechika, Bioorg. Med. Chem. Lett., 23(1), 81-84 (2013).

2012

  • Enhanced Lithium-Induced Brain Recovery Following Cranial Irradiation Is Not Impeded by Inflammation.
    J. Malaterre, C. S. McPherson, D. Denoyer, E. Lai, J. Hagekyriakou, S. Lightowler, K. Shudo, M. Ernst, D. M. Ashley, J. L. Short, G. Wheeler, and R. G. Ramsay, Stem Cells Trans. Med., 1(6), 469-479 (2012).
  • Tamibarotene: A Candidate Retinoid Drug for Alzheimer's Disease.
    H. Fukasawa, M. Nakagomi, N. Yamagata, H. Katsuki, K. Kawahara, K. Kitaoka, T. Miki, and K. Shudo, Biol. Pharm. Bull., 35(8), 1206-1212 (2012).
  • Natural and Synthetic Retinoids Afford Therapeutic Effects on Intracerebral Hemorrhage in Mice.
    H. Matsushita, M. Hijioka, A. Hisatsune, Y. Isohama, K. Shudo, and H. Katsuki, Eur. J. Pharmacol., 683(1-3), 125-131 (2012).
  • Retinoids Ameliorate Insulin Resistance in a Leptin-dependent Manner in Mice.
    H. Tsuchiya, Y. Ikeda, Y. Ebata, C. Kojima, R. Katsuma, T. Tsuruyama, T. Sakabe, K. Shomori, N. Komeda, S. Oshiro, H. Okamoto, K. Takubo, S. Hama, K. Shudo, K. Kogure, and G. Shiota, Hepatology, 56(4), 1319-1330 (2012).
  • (R)- and (S)-4-Amino-3-(trimethylsilyl)methylbutanoic Acids Ameliorate Neuropathic Pain without Central Nervous System-related Side Effects.
    H. Muratake, A. Ito, T. Toda, H. Suzuki, H. Fukasawa, M. Tsuda, K. Inoue, K. Sugiyama, and K. Shudo, Bioorg. Med. Chem. Lett., 22(24), 7602-7604 (2012).

2011

  • Retinoic Acid Receptor Antagonist LE540 Attenuates Wakefulness via the Dopamine D1 Receptor in Mice.
    K. Kitaoka, M. Shimizu, N. Shimizu, S. Chikahisa, M. Nakagomi, K. Shudo, K. Yoshizaki, and H. Séi, Brain Res., 1423, 10-16 (2011).
  • Diphenylamine-based Retinoid Antagonists: Regulation of RAR and RXR Function Depending on the N-substituent.
    K. Ohta, E. Kawachi, H. Fukasawa, K. Shudo, and H. Kagechika, Bioorg. Med. Chem., 19(8), 2501-2507 (2011).
  • Midbrain Dopaminergic Neurons Utilize Nitric Oxide/cyclic GMP Signaling to Recruit ERK that Links Retinoic Acid Receptor Stimulation to Up-regulation of BDNF.
    Y. Kurauchi, A. Hisatsune, Y. Isohama, T. Sawa, T. Akaike, K. Shudo, and H. Katsuki, J. Neurochem., 116(3), 323-333 (2011).
  • A Retinoic Acid Receptor Agonist Am80 Rescues Neurons, Attenuates Inflammatory Reactions, and Improves Behavioral Recovery after Intracerebral Hemorrhage in Mice.
    H. Matsushita, M. Hijioka, A. Hisatsune, Y. Isohama, K. Shudo, and H. Katsuki, J. Cereb. Blood Flow Metab., 31(1), 222-234 (2011).

2010

  • Synthesis and Application of [1,2,5]Triazepane and [1,2,5]Oxadiazepane as Versatile Structural Units for Drug Discovery.
    H. Suzuki, I. Utsunomiya, and K. Shudo, Chem. Pharm. Bull., 58(7), 1001-1002 (2010).
  • Novel Synthesis of Ureas: Application of t-Butylureas.
    A. Ito, H. Muratake, and K. Shudo, Chem. Pharm. Bull., 58(1), 82-86 (2010).

2009

  • Disposition of a New Tamibarotene Prodrug in Mice.
    M. Sugitani, R. Abe, N. Ikarashi, K. Ito, H. Muratake, K. Shudo, and K. Sugiyama, Biol. Pharm. Bull., 32(12), 1997-2001 (2009).
  • Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis.
    C. Klemann, B. J.E. Raveney, A. K. Klemann, T. Ozawa, S. von Hörsten, K. Shudo, S. Oki, and T. Yamamura, Am. J. Pathol., 174(6), 2234-2245 (2009).
  • Oral Administration of Synthetic Retinoid Am80 (Tamibarotene) Decreases Brain β-Amyloid Peptides in APP23 Mice.
    K. Kawahara, K. Nishi, M. Suenobu, H. Ohtsuka, A. Maeda, K. Nagatomo, A. Kuniyasu, M. Staufenbiel, M. Nakagomi, K. Shudo, and H. Nakayama, Biol. Pharm. Bull., 32(7), 1307-1309 (2009).
  • Retinoic Acid Receptor Stimulation Protects Midbrain Dopaminergic Neurons from Inflammatory Degeneration via BDNF-mediated Signaling.
    H. Katsuki, E. Kurimoto, S. Takemori, Y. Kurauchi, A. Hisatsune, Y. Isohama, Y. Izumi, T. Kume, K. Shudo, and A. Akaike, J. Neurochem., 110(2), 707-718 (2009).
  • Encapsulation of the Synthetic Retinoids Am80 and LE540 into Polymeric Micelles and the Retinoids' Release Control
    T. Satoh, Y. Higuchi, S. Kawakami, M. Hashida, H. Kagechika, K. Shudo, and M. Yokoyama, J. Control. Release, 136(3), 187-195 (2009).
  • On the Structure of “5-Nitrosotropolone”.
    A. Ito, H. Muratake, and K. Shudo, J. Org. Chem., 74(3), 1275-1281 (2009).
  • Towards Retinoid Therapy for Alzheimer's Disease.
    K. Shudo, H. Fukasawa, M. Nakagomi, and N. Yamagata, Curr. Alzheimer Res., 6(3), 302-311 (2009).
  • The Effect of Am-80, a Synthetic Retinoid, on Spinal Cord Injury-Induced Motor Dysfunction in Rats.
    M. Takenaga, Y. Ohta, Y. Tokura, A. Hamaguchi, K. Shudo, H. Okano, and R. Igarashi, Biol. Pharm. Bull., 32(2), 225-231 (2009).
  • Oral Administration of Synthetic Retinoid Am80 Inhibits the Development of Type 1 Diabetes in Non-obese Diabetic (NOD) Mice.
    M. Ishido and K. Shudo, Biol. Pharm. Bull., 32(1), 157-159 (2009).
  • The Transcription Factors Nur77 and Retinoid X Receptors Participate in Amphetamine-induced Locomotor Activities.
    E. Bourhis, J. Maheux, B. Paquet, H. Kagechika, K. Shudo, P. P. Rompré, C. Rouillard, and D. Lévesque, Psychopharmacology (Berl), 202(4), 635-648 (2009).
  • 【総説】 7 環性トリカブト毒 (±)-ノミニンの全合成
    村竹英昭 (H. Muratake) <分担執筆>, 天然物全合成の最新動向 (北泰行監修), 第 12 章, 175-190 (2009, シーエムシー出版).

2008

  • The RXR Agonists PA024 and HX630 Have Different Abilities to Activate LXR/RXR and to Induce ABCA1 Expression in Macrophage Cell Lines.
    T. Nishimaki-Mogami, N. Tamehiro, Y. Sato, K. Okuhira, K. Sai, H. Kagechika, K. Shudo, S. Abe-Dohmae, S. Yokoyama, Y. Ohno, K. Inoue, and J. Sawada, Biochem. Pharmacol., 76(8), 1006-1013 (2008).

2007

  • β-Cryptoxanthin, a Novel Natural RAR Ligand, Induces ATP-binding Cassette Transporters in Macrophages.
    A. Matsumoto, H. Mizukami, S. Mizuno, K. Umegaki, J. Nishikawa, K. Shudo, H. Kagechika, and M. Inoue, Biochem. Pharmacol., 74(2), 256-264 (2007).
  • タミバロテン (Tamibarotene).
    首藤紘一 (K. Shudo), 化学療法の領域 (ANTIBIOTICS & CHEMOTHERAPY), 23(4), 95-99(609-613) (2007).

2006

  • Synthetic Retinoid Am80 Reduces Scavenger Receptor Expression and Atherosclerosis in Mice by Inhibiting IL-6.
    N. Takeda, I. Manabe, T. Shindo, H. Iwata, S. Iimuro, H. Kagechika, K. Shudo, and R. Nagai, Arterioscler. Thromb. Vasc. Biol., 26(5), 1177-1183 (2006).
  • 【総説】 レチノイドによる自己免疫疾患の治療 (Retinoid Therapy for Autoimmune Diseases).
    深澤弘志 (H. Fukasawa), 影近弘之 (H. Kagechika), 首藤紘一 (K. Shudo), 日本臨床免疫学会会誌 (Jpn. J. Clin. Immunol.), 29(3), 114-126 (2006).
  • A New RXR Agonist, HX630, Suppresses Intimal Hyperplasia in a Mouse Blood Flow Cessation Model.
    G. Haraguchi, J. Suzuki, H. Kosuge, M. Ogawa, N. Koga, S. Muto, A. Itai, H. Kagechika, K. Shudo, and M. Isobe, J. Mol. Cell. Cardiol., 41(5), 885-892 (2006).
  • Synthetic Study of Hetisine-type Aconite Alkaloids. Part 1: Preparation of Tetracyclic Intermediate Containing the C14-C20 Bond.
    H. Muratake and M. Natsume, Tetrahedron, 62(29), 7056-7070 (2006).
  • Synthetic Study of Hetisine-type Aconite Alkaloids. Part 2: Preparation of Hexacyclic Compound Lacking the C-Ring of the Hetisan Skeleton.
    H. Muratake and M. Natsume, Tetrahedron, 62(29), 7071-7092 (2006).
  • Synthetic Study of Hetisine-type Aconite Alkaloids. Part 3: Total Synthesis of (±)-Nominine.
    H. Muratake, M. Natsume, and H. Nakai, Tetrahedron, 62(29), 7093-7112 (2006).
  • 【総説】 Hetisan 型アルカロイドの合成研究 —(±)-Nominine の全合成— (Synthetic Studies of Hetisan-Type Aconite Alkaloids —Total Synthesis of (±)-Nominine—).
    村竹英昭 (H. Muratake), 有機合成化学協会誌 (J. Synth. Org. Chem. Jpn.), 64(3), 237-250 (2006).

2005

  • Synthetic Retinoids: Recent Developments Concerning Structure and Clinical Utility.
    H. Kagechika and K. Shudo, J. Med. Chem., 48(19), 5875-5883 (2005).
  • Synthetic Retinoid Am80 Suppresses Smooth Muscle Phenotypic Modulation and In-Stent Neointima Formation by Inhibiting KLF5.
    K. Fujiu, I. Manabe, A. Ishihara, Y. Oishi, H. Iwata, G. Nishimura, T. Shindo, K. Maemura, H. Kagechika, K. Shudo, and R. Nagai, Circ. Res., 97, 1132-1141 (2005).
  • RXR Agonist Enhances the Differentiation of Cardiomyocytes Derived from Embryonic Stem Cells in Serum-free Conditions.
    M. Honda, T. S. Hamazaki, S. Komazaki, H. Kagechika, K. Shudo, and M. Asashima, Biochem. Biophys. Res. Commun., 333(4), 1334-1340 (2005).
  • HX531, a Retinoid X Receptor Antagonist, Inhibited the 9-Cis Retinoic Acid-induced Binding with Steroid Receptor Coactivator-1 as Detected by Surface Plasmon Resonance.
    T. Kanayasu-Toyoda, T. Fujino, T. Oshizawa, T. Suzuki, T. Nishimaki-Mogami, Y. Sato, J. Sawada, K. Inoue, K. Shudo, Y. Ohno, and T. Yamaguchi, J. Steroid Biochem. Mol. Biol., 94(4), 303-309 (2005).
  • Antimyeloma Effects of a Novel Synthetic Retinoid Am80 (Tamibarotene) through Inhibition of Angiogenesis.
    T. Sanda, T. Kuwano, S. Nakao, S. Iida, T. Ishida, H. Komatsu, K. Shudo, M. Kuwano, M. Ono, and R. Ueda, Leukemia., 19(6), 901-909 (2005).

2004

  • Modifying Effects of 1'-Acetoxychavicol Acetate (ACA) and the Novel Synthetic Retinoids Re-80, Am-580 and Am-55P in a Two-stage Carcinogenesis Model in Female Rats.
    S. Orita, M. Hirose, S. Takahashi, K. Imaida, N. Ito, K. Shudo, H. Ohigashi, A. Murakami, and T. Shirai, Toxicol. Pathol., 32(2), 250-257 (2004).
  • A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm.
    K. Shudo, H. Kagechika, N. Yamazaki, M. Igarashi, and C. Tateda, Biol. Pharm. Bull., 27(11), 1887-1889 (2004).
  • Differential Modulation of PI3-kinase/Akt Pathway During All-trans Retinoic Acid- and Am80-induced HL-60 Cell Differentiation Revealed by DNA Microarray Analysis.
    S. Ishida, Y. Shigemoto-Mogami, Y. Shinozaki, H. Kagechika, K. Shudo, S. Ozawa, J. Sawada, Y. Ohno, and K. Inoue, Biochem. Pharmacol., 68(11), 2177-2186 (2004).
  • Palladium-Catalyzed Intramolecular α-Arylation of Aliphatic Ketone, Formyl, and Nitro Groups.
    H. Muratake, M. Natsume, and H. Nakai, Tetrahedron, 60(51), 11783-11803 (2004).
  • Total Synthesis of (±)-Nominine, a Heptacyclic Hetisine-Type Aconite Alkaloid.
    H. Muratake and M. Natsume, Angew. Chem. Int. Ed., 43(35), 4646-4649 (2004).

2003

  • In Vitro Farnesoid X Receptor Ligand Sensor Assay Using Surface Plasmon Resonance and Based on Ligand-induced Coactivator Association.
    T. Fujino, Y. Sato, M. Une, T. Kanayasu-Toyoda, T. Yamaguchi, K. Shudo, K. Inoue, and T. Nishimaki-Mogami, J. Steroid. Biochem. Mol. BiolLett., 87(4-5), 247-252 (2003).

2002

  • Synthesis of a Compound Having the Essential Structural Unit for the Hetisine-type of Aconite Alkaloids.
    H. Muratake and M. Natsume, Tetrahedron Lett., 43(16), 2913-2917 (2002).

2000

  • Preparation of Benzene, Furan, and Thiophene Analogs of Duocarmycin SA Employing a Newly-Devised Phenol-Forming Reaction.
    H. Muratake, A. Hayakawa, and M. Natsume, Chem. Pharm. Bull., 48(10), 1558-1566 (2000).

1999

  • Intramolecular Cyclization Using Palladium-Catalyzed Arylation toward Formyl and Nitro Groups.
    H. Muratake and H. Nakai, Tetrahedron Lett., 40(12), 2355-2358 (1999).

1998

  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 15. Asymmetric Synthesis of (+)-Duocarmycin SA Using Novel Procedure for Preparation of Hydroxyindoles.
    H. Muratake, N. Matsumura, and M. Natsume, Chem. Pharm. Bull., 46(4), 559-571 (1998).
  • Synthesis of Duocarmycin SA by way of Methyl 4-(Methoxycarbonyl)-oxy-3H-pyrrolo[3,2-f]-quinoline-2-carboxylate as a Tricyclic Heteroaromatic Intermediate.
    H. Muratake, M. Tonegawa, and M. Natsume, Chem. Pharm. Bull., 46(3), 400-412 (1998).

1997

  • Palladium-Catalyzed Intramolecular α-Arylation of Aliphatic Ketones.
    H. Muratake and M. Natsume, Tetrahedron Lett., 38(43), 7581-7582 (1997).
  • A Novel Phenol-Forming Reaction for Preparation of Benzene, Furan, and Thiophene Analogs of CC-1065/Duocarmycin Pharmacophores.
    H. Muratake, A. Hayakawa, and M. Natsume, Tetrahedron Lett., 38(43), 7577-7580 (1997).
  • Synthesis of Furan and Thiophene Analogs of Duocarmycin SA.
    H. Muratake, K. Okabe, M. Takahashi, M. Tonegawa, and M. Natsume, Chem. Pharm. Bull., 45(5), 799-806 (1997).

1996

  • Alternative Synthesis of Duocarmycin SA Using a Tetracyclic Heteroaromatic Intermediate Prepared by Palladium-Catalyzed Coupling Reactions.
    H. Muratake, M. Tonegawa, and M. Natsume, Chem. Pharm. Bull., 44(8), 1631-1633 (1996).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 14. Synthesis of (±)-Duocarmycin SA, Natural (+)-Duocarmycin SA, and Non-natural (−)-Duocarmycin SA.
    H. Muratake, I. Abe, and M. Natsume, Chem. Pharm. Bull., 44(1), 67-79 (1996).

1995

  • Total Synthesis of Natural (+)-Duocarmycin SA.
    H. Muratake, N. Matsumura, and M. Natsume, Chem. Pharm. Bull., 43(6), 1064-1066 (1995).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 13. Enantiospecific Synthesis of Mitosene Analogues Related to FR900482 and FR88979.
    I. Utsunomiya, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 43(1), 37-48 (1995).

1994

  • Total Synthesis of Antitumor Antibiotic, (±)-Duocarmycin SA.
    H. Muratake, I. Abe, and M. Natsume, Tetrahedron Lett., 35(16), 2573-2576 (1994).
  • Total Synthesis of a Frog Poison, (±)-Epibatidine, a Potent Non-opioid Analgesic.
    K. Okabe and M. Natsume, Chem. Pharm. Bull., 42(7), 1432-1436 (1994).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 12. Enantiospecific Synthesis of Hapalindole O.
    M. Sakagami, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 42(7), 1393-1398 (1994).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 11. Total Synthesis of (6R,8S)-Herbindole A, (6R,8S)-Herbindole B, (6R,8S)-Herbindole C, (6R,8S)-cis-Trikentrin A, (6R,8S)-cis-Trikentrin B, (6R,8R)-trans-Trikentrin B, and (6R,8R)-iso-trans-Trikentrin B. Determination of the Absolute Structures of Natural Herbindoles and Trikentrins.
    H. Muratake, A. Mikawa, T. Seino, and M. Natsume, Chem. Pharm. Bull., 42(4), 854-864 (1994).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 10. Synthesis of 4- and/or 5-Alkylated 1,6,7,8-Tetrahydrocyclopent[g]indoles, Model Compounds for Herbindole and Trikentrin Syntheses.
    H. Muratake, A. Mikawa, T. Seino, and M. Natsume, Chem. Pharm. Bull., 42(4), 846-853 (1994).

1993

  • Total Synthesis of (6R,8S)-cis-Trikentrin B, (6R,8R)-trans-Trikentrin B, and (6R,8R)-iso-trans-Trikentrin B. Determination of the Absolute Structures of the Natural Trikentrins B.
    H. Muratake, T. Seino, and M. Natsume, Tetrahedron Lett., 34(30), 4815-4818 (1993).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 9. Synthesis of (1aS,8bS)-1-tert-Butyloxycarbonyl-8-formyl-1,1a,2,8b-tetrahydroazirino [2',3':3,4]pyrrolo[1,2-a]indole. Model Study for the Enantiospecific Synthesis of Aziridinomitosenes.
    I. Utsunomiya, M. Fuji, T. Sato, M. Natsume, Chem. Pharm. Bull., 41(5), 854-860 (1993).

1992

  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 8. Improved Practical Synthesis of 4,4-Dialkoxy-1-(1-arylsulfonyl-3-pyrrolyl)-1-butanone and 4-(1-Arylsulfonyl-3-pyrrolyl)-4-oxobutanal, and a Novel Synthetic Procedure for 4-Alkoxyindole Derivatives.
    I. Utsunomiya, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 40(9), 2358-2361 (1992).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 7. Synthesis of (±)-and (S)-(−)-Pindolol.
    M. Fuji, H. Muratake, M. Akiyama, and M. Natsume, Chem. Pharm. Bull., 40(9), 2353-2357 (1992).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 6. Synthetic Procedure for 4-, 5-, 6- or 7-Alkoxy- and Hydroxyindole Derivatives.
    M. Fuji, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 40(9), 2344-2352 (1992).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion, Part 5. Efficient Preparative Procedure for 4-Substituted Indole Derivatives.
    M. Fuji, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 40(9), 2338-2343 (1992).
  • Total Synthesis of (+)-Herbindole A, (+)-Herbindole B, and (+)-Herbindole C. Determination of the absolute Configuration of the Natural Herbindoles.
    H. Muratake, A. Mikawa, and M. Natsume, Tetrahedron Lett., 33(32), 4595-4598 (1992).
  • Synthesis of (±)-Tetrahydropseudodistomin, a Hydrogenation Product of Antineoplastic Alkaloids, Pseudodistomins A and B.
    I. Utsunomiya, M. Ogawa, and M. Natsume, Heterocycles, 33(1), 349-356 (1992).

1991

  • Synthesis of Teleocidins A, B and Their Congeners. Part 3. Synthesis of Dihydroteleocidin B-4 (Dihydroteleocidin B), Teleocidin B-3 and Teleocidin B-4.
    K. Okabe, H. Muratake, and M. Natsume, Tetrahedron, 47(40), 8559-8572 (1991).
  • Synthesis of Teleocidins A, B and Their Congeners. Part 2. Synthesis of Lyngbyatoxin A (Teleocidin A-1), Teleocidin A-2, Pendolmycin, and (R,E)- and (S,E)-7-(3,7,11-Trimethyl-1,6,10-dodecatrien-3-yl)-(−)-indolactams V.
    H. Muratake, K. Okabe, and M. Natsume, Tetrahedron, 47(40), 8545-8558 (1991).
  • Synthesis of Teleocidins A, B and Their Congeners. Part 1. An Efficient Synthesis Method of N-(7-Alkyl-4-indolyl)-N-methyl-L-valine Esters, Essential Intermediates for Teleocidin Synthesis.
    H. Muratake and M. Natsume, Tetrahedron, 47(40), 8535-8544 (1991).
  • The Second Generation Synthesis of a Tumor Promoter Pendolmycin.
    K. Okabe and M. Natsume, Tetrahedron, 47(36), 7615-7624 (1991).
  • Pendolmycin, a New Tumor Promoter of the Teleocidin A Class on Skin of CD-1 Mice.
    S. Nishiwaki, H. Fujiki, S. Yoshizawa, M. Suganuma, H. Furuya-Suguri, S. Okabe, M. Nakayasu, K. Okabe, H. Muratake, and M. Natsume, Jpn. J. Cancer Res., 82(7), 779-783 (1991).

1990

  • Synthetic Studies of Marine Alkaloids Hapalindoles. Part 3. Total Synthesis of (±)-Hapalindoles H and U.
    H. Muratake, H. Kumagami, and M. Natsume, Tetrahedron, 46(18), 6351-6360 (1990).
  • Synthetic Studies of Marine Alkaloids Hapalindoles. Part 2. Lithium Aluminum Hydride Reduction of the Electron-Rich Carbon-Carbon Double Bond Conjugated with the Indole Nucleus.
    H. Muratake and M. Natsume, Tetrahedron, 46(18), 6343-6350 (1990).
  • Synthetic Studies of Marine Alkaloids Hapalindoles. Part 1. Total Synthesis of (±)-Hapalindoles J and M.
    H. Muratake and M. Natsume, Tetrahedron, 46(18), 6331-6342 (1990).
  • Total Synthesis of Indole Alkaloid Pendolmycin.
    K. Okabe, H. Muratake, and M. Natsume, Tetrahedron, 46(15), 5113-5120 (1990).
  • Synthesis of (±)- and (−)-cis-Trikentrin A, (±)- and (−)-trans-Trikentrin A, (±)-cis-Trikentrin B, (±)-trans-Trikentrin B, and (±)-iso-trans-Trikentrin B.
    H. Muratake, M. Watanabe, K. Goto, and M. Natsume, Tetrahedron, 46(12), 4179-4192 (1990).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 4.
    H. Muratake and M. Natsume, Heterocycles, 31(4), 691-700 (1990).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 3.
    H. Muratake and M. Natsume, Heterocycles, 31(4), 683-690 (1990).

1989

  • Determination of the Absolute Structures of cis-Trikentrin A and trans-Trikentrin A by Synthesis of Their Enantiomers.
    H. Muratake and M. Natsume, Tetrahedron Lett., 30(42), 5771-5772 (1989).
  • Total Synthesis of Marine Alkaloids (±)-Hapalindoles J and M.
    H. Muratake and M. Natsume, Tetrahedron Lett., 30(14), 1815-1818 (1989).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 2.
    H. Muratake and M. Natsume, Heterocycles, 29(4), 783-794 (1989).
  • Preparation of Alkyl-Substituted Indoles in the Benzene Portion. Part 1.
    H. Muratake and M. Natsume, Heterocycles, 29(4), 771-782 (1989).
  • Synthesis of Optically Active Teleocidins B-3 and B-4.
    K. Okabe, H. Muratake, and M. Natsume, Chem. Pharm. Bull., 37(2), 563-564 (1989).

1988

  • Total Synthesis of Dihydroteleocidin B-4 (Dihydroteleocidin B).
    H. Muratake, K. Okabe and M. Natsume, Tetrahedron Lett., 29(48), 6267-6270 (1988).
  • インドールアルカロイド及び関連化合物合成の最近の展開 (A Recent Development of the Synthesis of Indole Alkaloids and Related Substances).
    夏目充隆 (M. Natsume), 薬学雑誌 (Yakugakuzasshi), 108(2), 109-128 (1988). (昭和62年度日本薬学会年会特別講演)

1987

  • A High Yield Cyclization Reaction for the Framework of Aspidosperma Alkaloids Synthesis of (±)-Kopsinine and its Related Alkaloids.
    M. Ogawa, Y. Kitagawa, and M. Natsume, Tetrahedron Lett., 28(34), 3985-3986(1987).
  • Total Synthesis of Lyngbyatoxin A (Teleocidin A-1) and Teleocidin A-2.
    H. Muratake and M. Natsume, Tetrahedron Lett., 28(20), 2265-2268 (1987).

1986

  • 【総説】 一重項酸素の合成化学への応用 (Application of Singlet Oxygen for Synthetic Chemistry).
    夏目充隆 (M. Natsume), ファルマシア (Farumashia), 22, 335-338 (1986).
  • 【総説】 ピペリジン環を含むアルカロイド類の合成 (A Synthetic Study of Alkaloids Containing Piperidine Ring).
    夏目充隆 (M. Natsume), 有機合成化学協会誌 (J. Synth. Org. Chem. Jpn.), 44(4), 326-339 (1986).

1985

  • A New Synthetic Method for the Framework of Aspidosperma Alkaloids Using Singlet Oxygen Chemistry.
    M. Natsume, I. Utsunomiya, K. Yamaguchi, and S. Sakai, Tetrahedron, 41(11), 2115-2123 (1985).
  • Total Synthesis of (±)-α-Cyclopiazonic Acid.
    H. Muratake and M. Natsume, Heterocycles, 23(5), 1111-1117 (1985).
  • Synthesis of the Sedum Alkaloid Sedinine.
    M. Ogawa and M. Natsume, Heterocycles, 23(4), 831-834 (1985).

1984

  • Total Synthesis of (±)-Palustrine and Structure Revision.
    M. Natsume and M. Ogawa, Chem. Pharm. Bull., 32(9), 3789-3791 (1984).
  • A New Synthesis of (±)-Vindorosine.
    M. Natsume and I. Utsunomiya, Chem. Pharm. Bull., 32(6), 2477-2479 (1984).
  • Synthesis of a Compound Having a Palustrine Structure.
    M. Natsume, M. Ogawa, I. Yoda, and M. Shiro, Chem. Pharm. Bull., 32(2), 812-814 (1984).
  • Total Synthesis of (±)-Cannabisativine.
    M. Ogawa, N. Kuriya, and M. Natsume, Tetrahedron Lett., 25(9), 969-972 (1984).

1983

  • Total Synthesis of (±)-Clavicipitic Acids I and II.
    H. Muratake, T. Takahashi, and M. Natsume, Heterocycles, 20(10), 1963-1968 (1983).
  • Application of the Oxygenative Nucleophile Introduction Reaction to 1-Alkoxycarbonyl-2-alkynyl-1,2-dihydropyridines. A Facile Synthesis of (±)-Sedacryptine.
    M. Natsume and M. Ogawa, Heterocycles, 20(4), 601-605 (1983).

1982

  • Stable Conformation of 2,6-cis-Disubstituted 1-Acyl-1,2,3,6-tetrahydropyridines and Stereoselective Formation of Palustrine Side Chain.
    M. Natsume and M. Ogawa, Chem. Pharm. Bull., 30(9), 3442-3445 (1982).
  • Stereoselective Synthesis of (±)-18-Deoxypalustrine and (±)-Deoxy-13-epipalustrine.
    M. Ogawa, J. Nakajima, and M. Natsume, Heterocycles, 19(7), 1247-1252 (1982).
  • Stereoselective Synthesis of (±)-Deethylaspidospermidine.
    M. Natsume and I. Utsunomiya, Heterocycles, 17(1), 111-115 (1982).

1981

  • An Alternative Synthesis of (±)-Dihydrosetoclavine.
    M. Natsume and H. Muratake, Heterocycles, 16(9), 1481-1486 (1981).
  • Total Synthesis of Prosophylline.
    M. Natsume and M. Ogawa, Heterocycles, 16(6), 973-977 (1981).
  • Synthesis of an Intermediate to the Tetracyclic Ergot Alkaloids.
    M. Natsume, H. Muratake, and Y. Kanda, Heterocycles, 16(6), 959-962 (1981).
  • Total Syntheses of (±)-Chanoclavine I and (±)-Dihydrosetoclavine.
    M. Natsume and H. Muratake, Heterocycles, 16(3), 375-379 (1981).
  • A Facile Synthesis of a Nuphar Alkaloid, Nupharolutine.
    M. Natsume and M. Ogawa, Heterocycles, 15(1), 237-240 (1981).

1980

  • Total Synthesis of (±)-6,7-Secoagroclavine.
    M. Natsume and H. Muratake, Heterocycles, 14(8), 1101-1105 (1980).
  • Stereoselective Synthesis of dl-Prosafrinine and dl-Pseudocarpamic Acid.
    M. Natsume and M. Ogawa, Heterocycles, 14(5), 615-618 (1980).
  • A Stereoselective Synthesis of dl-3-Epiuleine.
    M. Natsume and Y. Kitagawa, Tetrahedron Lett., 21(9), 839-840 (1980).
  • Useful Intermediate for the Synthesis of Ergot Alkaloids.
    M. Natsume and H. Muratake, Heterocycles, 14(4), 445-448 (1980).
  • Stereoselective Synthesis of dl-Carpamic Acid and dl-Azimic Acid.
    M. Natsume and M. Ogawa, Heterocycles, 14(2), 169-173 (1980).

1979

  • A Carbon-Carbon Bond Formation Using an Endoperxide of N-Methoxycarbonylpyrrole and a Convenient Synthesis of 4-Alkylindoles.
    M. Natsume and H. Muratake, Tetrahedron Lett., 20(36), 3477-3480 (1979).
  • A Carbon-Carbon Bond Formation Using Endoperxides of 1,2-Dihydropyridines.
    M. Natsume, Y. Sekine, M. Ogawa, H. Soyagimi, and Y. Kitagawa, Tetrahedron Lett., 20(36), 3473-3476 (1979).

1978

  • Synthetic Study of Amino-sugars from Pyridines. V. Synthesis of 5-Amino-5-deoxypiperidinoses from the Singlet Oxygen Adduct of 1-Acyl-1,2-dihydropyridines. (2)
    M. Natsume, M. Wada, and M. Ogawa, Chem. Pharm. Bull., 26(11), 3364-3372 (1978).
  • A Novel N-Amination method and Its Application to the Preparation of N-Aminoheterocycles.
    M. Somei, M. Matsubara, Y. Kanda, and M. Natsume, Chem. Pharm. Bull., 26(8), 2522-2534 (1978).
  • Synthetic Study of Amino-sugars from Pyridines. IV. Synthesis of 5-Amino-5-deoxypyperidinoses from the Singlet Oxygen Adduct of 1-Acyl-1,2-dihydropyridines. (1).
    M. Natsume, Y. Sekine, and H. Soyagimi, Chem. Pharm. Bull., 26(7), 2188-2197(1978).

1977

  • Antitumor Activity of N-Heterocyclic Carboxaldehyde Thiosemicarbazone Derivatives.
    M. Iigo, A. Hoshi, K. Kuretani, M. Natsume, and M. Wada, Gann, 68(2), 221-225 (1977).

1976

  • Synthetic Studies on Amino-sugars from Pyridines. III. Synthesis of 1-O-Methyl-5-benzamido-5-deoxy-dl-idopiperidinose.
    M. Natsume and M. Wada, Chem. Pharm. Bull., 24(11), 2657-2660 (1976).
  • Synthetic Studies on Amino-sugars from Pyridines. II. Synthesis of 5-Methoxycarbonylamino-5-deoxy-dl-xylopiperidinose Tetraacetate.
    M. Natsume and M. Wada, Chem. Pharm. Bull., 24(11), 2651-2656 (1976).

1975

  • The Chemistry of Indoles. IV. Preparation of Pyridazino[2,3-a]indoles and as-triazino[1,6-a]indoles.
    M. Somei, M. Matsubara, and M. Natsume, Chem. Pharm. Bull., 23(11), 2891-2898 (1975).
  • Synthetic Studies on Amino-sugars from Pyridines. I. Synthesis of 1-O-Methyl-N-benzoyl-dl-nojirimycin.
    M. Natsume and M. Wada, Chem. Pharm. Bull., 23(11), 2567-2572 (1975).

1974

  • The Chemistry of Indoles (1-Aminoindoles), III.
    M. Somei and M. Natsume, Tetrahedron Lett., 15(41), 3605-3608 (1974).
  • An Application of the Photocyclization Reaction of Schiff Bases to the Synthesis of a Phenanthridine Alkaloid.
    T. Onaka, Y. Kanda, and M. Natsume, Tetrahedron Lett., 15(13), 1179-1180 (1974).
  • 1-Aminoindoles.
    M. Somei and M. Natsume, Tetrahedron Lett., 15(5), 461-462 (1974).

1973

  • Photochemical Rearrangements for the Syntheses of 3-, 4-, and 6-Substituted Indoles.
    M. Somei and M. Natsume, Tetrahedron Lett., 14(27), 2451-2454 (1973).
  • Reduction of Quinoline and Isoquinoline with Sodium Hydride.
    M. Natsume, S. Kumadaki, Y. Kanda, and K. Kiuchi, Tetrahedron Lett., 14(26), 2335-2338 (1973).

1972

  • Synthesis of 3H-4,5-Dihydro-3-benzazepine Derivatives from Isoquinolines.
    M. Natsume and M. Wada, Chem. Pharm. Bull., 20(8), 1836-1838 (1972).
  • Formation of 3-Cyano-1,4-dihydroquinolines and Their Conversion to Indole Derivatives.
    M. Natsume and I. Utsunomiya, Chem. Pharm. Bull., 20(7), 1595-1598 (1972).
  • 1,1-Disubstituted 1,2,3,4-Tetrahydroisoquinoline Derivatives from Isoquinolines.
    M. Natsume, S. Kumadaki, and K. Kiuchi, Chem. Pharm. Bull., 20(7), 1592-1595 (1972).
  • The Reaction of 4-Cyanoisoquinolines with the Grignard Reagent and Carbaions.
    M. Natsume and M. Wada, Chem. Pharm. Bull., 20(7), 1589-1592 (1972).

1971

  • Photochemical Addition of Alcohol, Esters, Ethers, and Amides to the Aromatic N-Heterocycles.
    M. Natsume and M. Wada, Tetrahedron Lett., 12(47), 4503-4506 (1971).
  • Wittig Reaction of N-Sulfonyl lactam.
    M. Natsume, M. Takahashi, K. Kiuchi, and H. Sugaya, Chem. Pharm. Bull., 19(12), 2648-2651 (1971).
  • A Note on a New Synthesis of N-Methylmorphinans. II.
    M. Natsume and S. Kumadaki, Itsuu Kenkyusho Nenpo, 16, 47-51 (1971).
  • Free Radical Reactions of Aromatic Amine N-Oxides. III. Free Radical Arylation of Aromatic Amine N-Oxides.
    M. Natsume, S. Kumadaki, and R. Tanabe, Itsuu Kenkyusho Nenpo, 16, 25-39 (1971).

1968

  • Free Radical Reactions on Aromatic Amine N-Oxides. II. Syntheses of Model Intermediates for Isoquinoline and Indole Alkaloids.
    M. Natsume and R. Tanabe, Itsuu Kenkyusho Nenpo, 15, 21-27 (1968).
  • Free Radical Reactions on Aromatic Amine N-Oxides. I. Five-step Synthesis of N-Alkylmorphinan.
    M. Natsume, S. Natsume, and T. Itai, Itsuu Kenkyusho Nenpo, 15, 9-19 (1968).
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